Sign Posts of Dr. Roy Walford chronicles the life of an eccentric artist-philosopher and award-winning research scientist in the field of gerontology, with a specialty in calorie restriction. This documentary features his obsession with life, death, poetry, politics, theater, women, and radicalism. His research at the University of California in Los Angeles spanned forty years and won him the highest respect from 'his peers. But it was his thirst for life, adventure, and freedom that sent him to live in India for a year, to travel alongside the Living Theater, to create music videos, and to embark on the maiden two-year voyage inside the hermetically sealed Biosphere 2 in 1991. This story is about a man with a vision, a man who broke social boundaries, a man who dared to live it all.