A young man enters a village named Shirdi and goes back to the Himalayas after spending some time there in meditation. He returns to Shirdi as a grown-up and displays miracles after which he is named as Sai Baba. Shirdi Sai showcases the life of Shirdi Sai Baba (Akkineni Nagarjuna) and his ardent devotees as well as people who tested him and realised his powers.